Biochemistry of Smooth Muscle Contraction, Michael Barany

This useful useful resource provides a systematic account of the biochemistry of smooth muscle contraction. As a comprehensive information to this rapidly growing space of analysis, it covers the construction and characteristic properties of contractile and regulatory proteins, with special emphasis on their predicted function in the stay muscle. Additionally included in this book are intermediate filament proteins, and desmin and vimentin, whose operate in clean muscle is unknown; and several enzymes concerned within the phosphorylation-dephosphorylation of contractile and other proteins.

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Pediatric Psychopharmacology: Principles and Practice, Andres Martin

Pediatric Psychopharmacology: Principles and Observe is an authoritative and comprehensive text on the usage of medicine within the treatment of youngsters and adolescents with serious neuropsychiatric disorders. This benchmark volume consists of fifty six chapters written by internationally acknowledged leaders, and is divided into four interrelated sections. The first, Biological Bases of Pediatric Psychopharmacology, opinions key rules of neurobiology and the key psychiatric diseases of childhood from a perspective rooted in developmental psychopathology. The second, Somatic Interventions, presents the foremost classes of psychiatric drugs, in addition to complementary and alternative somatic interventions, similar to electroconvulsive therapy (ECT), transcranial magnetic stimulation (rTMS), and naturopathic approaches. The third and longest section, Assessment and Remedy,begins with medical assessment, diagnostic evaluation, and complete remedy planning, and goes on to cowl the evidence-based analysis of drug remedies for the key disorders. Particular populations (equivalent to children with comorbid psychological retardation, substance abuse or medical sickness) are specifically mentioned, and the coordination of their remedy with non-somatic therapies is explicitly addressed. The ultimate section, Epidemiologic, Analysis, and Methodological Considerations, deals with broad inhabitants-relevant subjects reminiscent of regulation and policy, pharmacoepidemiology, and the critical importance of sound moral ideas for medical investigation. The e-book concludes with an appendix on generic and business drug name equivalencies, preparations, and accessible dosages.
This timely text is intended for baby and adolescent psychiatrists, common and developmental pediatricians, family practitioners, general psychiatrists, and different mental well being professionals who work with children and adolescents.

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Water-Insoluble Drug Formulation, Second Edition

Scientists have attributed more than 40 percent of the failures in new drug growth to poor biopharmaceutical properties, particularly water insolubility. Issues surrounding water insolubility can postpone, or utterly derail, vital new drug development. Even much-wanted reformulation of at present marketed merchandise may be significantly affected by these challenges.
Water Insolubility is the Primary Wrongdoer in over 40% of New Drug Development Failures

Probably the most comprehensive useful resource on the subject, this second edition of Water Insoluble Drug Formulation brings collectively a distinguished group of specialists to supply the scientific background and step-by-step steerage wanted to cope with solubility points in drug development. Twenty-three chapters systematically describe solubility properties and their impression on formulation, from concept to industrial practice. With detailed discussion on how these properties contribute to solubilization and dissolution, the textual content additionally options six model new chapters on water-insoluble medicine, exploring regulatory features, pharmacokinetic behavior, early section formulation methods, lipid based methods for oral delivery, modified release of insoluble drugs, and scalable manufacturing aspects. The e book includes more than 15 water-insoluble drug delivery methods or applied sciences, illustrated with case research featuring oral and parenteral applications. Highlighting the most current info and information out there, this seminal volume displays the numerous progress that has been made in nearly all aspects of this field.

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Targeted Delivery of Small and Macromolecular Drugs, Ajit S. Narang

Web site-specific drug delivery and targeting is attracting a lot research curiosity from both academia and industry, but due to the numerous challenges confronted in the growth of these techniques, solely a handful of focused therapies have successfully made it into clinical practice. Bringing collectively leading field consultants, Focused Delivery of Small and Macromolecular Medicine summarizes present progress with a deal with the novel ideas being explored to beat these challenges.

Focuses on the Targeted Drug Delivery Technologies that Utilize
each Systemic and Local Routes of Administration
Main specialists discuss some of the most promising strategies for drug targeting. They also cowl targeted drug delivery platforms and applied sciences at various stages of scientific and preclinical improvement, together with:

• Active targeting
• Nucleic acid delivery and targeting
• Intracellular/Organelle-Specific Strategies
• Prodrug Methods
• Organ or Tissue-Particular drug delivery
• Drug-Polymer Conjugates and Micelles
• Stimuli-Responsive methods

Targeted Delivery of Small and Macromolecular Drugs demonstrates why focused supply is one of the most fun contributions pharmaceutical sciences can make to drug therapy.

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Applications And Engineering Of Monoclonal Antibodies,David J. King

A worthwhile useful resource for researchers and staff within the fields of both prescription drugs and biotechnology in addition to undergraduates in biochemistry, applied biology, biomedical sciences and pharmacy, this book compares established methods of antibody production with the new. Antibody construction and the implications of antibody engineering are absolutely mentioned, and a case research method illustrates how antibodies are finding increasing use in the prognosis and treatment of disease. The amount ends with industrial expression, purification and enormous-scale manufacture of antibodies and their future potential, particularly as therapeutic agents.

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Fern Ecology, Klaus Mehltreter

Ferns are an integral a part of the world's flora, appreciated for his or her beauty as ornamentals, problematic as invaders and endangered by human interference. They usually dominate forest understories, but in addition colonize open areas, invade waterways, and survive nutrient-poor wastelands and eroded pastures. This is the primary complete summary of fern ecology, with worldwide examples from Siberia to Hawaii. Subjects include a brief history of the ecological study of ferns, their biogeography and population dynamics, their role in ecosystem nutrient cycles and diversifications to xeric environments, and their responses to disturbance and interactions with other organisms. Fully illustrated ideas provide a framework for college kids and professionals in ecology, conservation, and land administration, and a wealth of information for anyone excited by ferns.

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Prodrugs: Challenges and Rewards, Valentino Stella

These volumes represent a comprehensive guide to prodrugs. They guide the reader through the current status of the prodrug concept and its many applications and highlight its many successes in overcoming formulation and delivery of problematic drugs. Replete with examples of approved and marketed prodrugs, these volumes introduce the topic to the novice as well as professional in the design of prodrugs.

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Disease Management, 2nd Edition

This is a medical pharmacy textbook that applies pharmacology into observe utilizing a holistic strategy to the administration, treatment and monitoring of varied diseases. Pharmacy undergraduate educating has been changing and evolving through the years to reflect the evolving function of the pharmacist. The undergraduate syllabus is shifting more towards medical pharmacy because the role of the pharmacist adjustments to more of a consultancy position involving affected person care. This book has at all times aimed to address this variation by making use of pharmacology into medical practice utilizing a holistic approach. Taking widespread illnesses by system, this e-book deals with the frequent therapeutic issues. Every section includes an overview/description of the illness, medical features, pharmacology of therapeutics used to monitor the situation, remedy pointers, interactions and counselling of the patient. Drug selection tables and interactions tables are included along with case research, observe factors and self-assessment questions. Following are the amendments for this re-creation: all chapters are updated to incorporate steering; introduction chapter can be fully rewritten; it features major updates to responding to signs, lifestyle and antagonistic drug reaction chapters; it contains new chapters on Weight problems and Parkinson's illness; more diagrams are added, including diagnostic move charts/algorithms; and, it incorporates self evaluation questions.

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Olives and Olive Oil in Health and Disease Prevention

Long used in sacred ceremonies and associated with good health, the dietary and well being selling advantages of olives and olive oils have been proven by an ever-growing body of science. From cardiovascular advantages to anti-microbial, anti-most cancers, antioxidant activity and effects on macrophages and aptoptosis to cellular and pathophysiollogical process, olives and olive oils are proving vital in lots of healthful ways.

For example, reactive elements in olive oils or olive oil by-products have now been isolated and identified. These embody tyrosol, hydroxytyrosol, three,four-dihydroxyphenyl acetic acid elenolic acid and oleuropein. Oleic acid is the principle monosaturated fatty acid of olive oil. These have putative protective results and modulate the biochemistry of quite a lot of cell sorts including these of the vascular system. Some however not all parts have been characterised by their putative pharmacological properties. It's possible that utilization of these aforementioned products could have helpful application in different disease. Nevertheless, to ensure that this cross-fertilization to happen, a comprehensive understanding of olives and olive oils is required. Discovering this data in a single quantity gives a key useful resource for scientists in a variety of food an dietary roles.

Key Options:
* Explores olives and olive oil from their common features to the detailed stage of vital micro-and micronutrients
* Consists of protection of varied methodologies for evaluation to assist scientists and chemists determine essentially the most applicable choice for their own studies, together with these of olive-associated compounds in other foods
* Relates, in a single volume resource, data for meals and nutritional chemists, pharmaceutical scientists, nutritionists and dieticians
* Presents information in three key categories: Basic aspects of olives an olive oils; Dietary, pharmacological and metabolic properties of olives and olive oil; Particular elements of olive oil and their results on tissue and body techniques

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Narcolepsy: A Clinical Guide, Meeta Goswami

This interdisciplinary quantity brings collectively lots of the world’s leading clinicians and researchers to discuss present and anticipated developments in the understanding of narcolepsy. The quantity is broadly divided into four principal sections: Section I: Etiology; Section II: Scientific Concerns; Section III: Psychosocial considerations; and Part IV: Management. The areas covered embody findings from research investigations on the genetic predisposition and pathophysiology, psychosocial aspects, and scientific administration of narcolepsy by the use of pharmacological and non-pharmacological methods. Particular consideration is paid to the translational elements of narcolepsy. This volume is suitable for sleep problems specialists and researchers, psychiatrists, neurologists, psychologists, social workers, behavioral scientists, graduate medical college students, and any professionals and researchers interested in the interdisciplinary area of sleep medicine. Key Options · Give attention to issues faced in day-to-day clinical settings - helps to tell and alter medical follow; · Chapters deal with both scientific and analysis basis - highlights potential areas of future analysis; · Interdisciplinary and translational approach - suitable for a wide range of clinicians and biomedical professionals.

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Pharmaceutical Microbiology, Stephen P. Denye

On this work, particular attention has been duly paid to the presentation of every chapter that primarily consists of: transient introduction, theoretical elements, classification, neat and vivid diagramatic illustrations of figures-graphics-equipments, lucid explanations, supportive classical examples, and profusely supplemented with explanatory 'foot notes'-references in addition to additional reading bibliography. The textual content content material runs over ten chapters that will show to be of paramount curiosity and massive readability not solely confined to the B.Pharm, college students but also to varied M.Sc., educational curricula in such disciplines as : Meals Microbiology, Environmental Science, Microbiology etc. Key features embody : concise and exhaustive presentation of scientific informations from a number of sources; a wealth of theoretical info that opens newer prospects; detailed classification of assorted microbial points; pharmaceutical assays and methodologies; comprehensive index consists of important terminologies; and, effectively documented statement of facts. About the Writer: Ashutosh Kar is a widely known Professor of Pharmaceutical Chemistry, presently, instructing at Shri RNS College of Pharmacy, Gormi, Bhind (M.P.). He has to his credit score twenty-seven years educating experience at undergraduate and graduate ranges each in Indian Universities and abroad. He has revealed more than twenty analysis papers based mostly on pharmacological research on natural and synthetic medication in worldwide and nationwide scientific journals. He has taught at College of Pharmacy, Addis Ababa University, Addis Ababa (Ethiopia) (2002-2005); Guru Jhambheshwar University, Hisar (India) (1999-2002); Al-Arab Medical College, Benghazi, (Libya) (1997-1998); Faculty of Pharmacy (University of Delhi), Delhi (India) (1990-1994); and, Faculty of Pharmaceutical Sciences, University of Nigeria, Nsukka (Nigeria) (1976-1987). Professor Kar has a wonderful monitor record in tutorial institutions of excessive reputation, and actively engaged in teaching, analysis, administration, and repair to his profession. He has to his credit greater than fifty analysis papers, and guided several PG/Ph.D., college students in Nigeria, India, and Ethiopia. He has bagged the College Gold Medal in B. Pharm., and M. Pharm., examinations from the University of Saugar, Saugor (M.P.) and accomplished his Ph.D. He's the life member of several national professional bodies like: APTI, IPGA, and ISTE. Professor Kar has been conferred with 'Lifetime Achievement Award, 2008', by the Indian Affiliation of Pharmaceutical Scientists and Technologists, Kolkata for his immerse contribution in the Indian Pharmacy Profession on the 19th January, 2008. Professor Kar has accomplished nine textbooks, particularly: "Medicinal Chemistry (4th/Version: 2006)"; "Pharmaceutical Drug Analysis (2nd/Version: 2005)"; "Pharmacognosy and Pharmacobiotechnology (2nd/Edition: 2006)"; "Superior Practical Medicinal Chemistry (2004)"; "Pharmaceutical Biotechnology [2005 (HB) & 2006 (PB)]"; "Pharmaceutical Microbiology (2006)"; "Pharmaceutical Pharmacology (2009)"; "Pharmaceutical Evaluation Quantity I (2007)"; and "Pharmaceutical Analysis Volume II (2009)". In addition to, Professor Kar's ten yr stint of commercial experience in Public Limited Companies as: Basic Supervisor (R&D), Production Manager (Food), and Research and Improvement Officer has inculcated in him an amazing in-constructed stimulus of refined research educational laboratories each within the African Continent and prime-notch Indian Universities.

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Psychotropic Drug Handbook, Paul Perry

 This blunt handbook provides acceptance and practitioners with clinically accordant consciousness-expanding biologic information. The Eighth Copy is advised as a advertence argument that aswell teaches by carrying advisory anecdotal argument beneath accepted account with references. Its focus goes above biologic advice to awning pharmacotherapy applications.

The book provides detailed, well-referenced, evidence-based advice on a advanced ambit of consciousness-expanding drugs, including affection stabilizers, antidepressants, and antianxiety agents. This copy has new capacity on pediatric and aged psychopharmacotherapy; new agreeable on antipsychotics, hypnotics, medications acclimated in alleviative alcoholism and actuality dependence, and electroconvulsive therapy; and new algorithms, appendices, and tables.

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Protein Engineering For Industrial Biotechnology, Lilia Alberghina

Protein engineering has accepted to be one of the added abounding abstruse approaches in biotechnology, getting both actual able and able to accomplish admired bookish property. This book aims to present examples in which the appliance of protein engineering has auspiciously apparent problems arising in automated biotechnology. There is a area on its use to enhance ablution of recombinant proteins. The use of protein engineering to adapt the action or the adherence of automated enzymes from lipases to proteases, from carboxypeptidases to glucanases and glucosidases, and from pectin modifying enzymes to enzymes able to abase contrary compounds is abundantly covered. It is apparent how areas as assorted as agrofood technology, accomplished chemistry, detergents, bioremediation and biosensors accept cogent contributions from protein and bread-and-butter engineering.

The appliance of protein engineering to bloom affliction is aswell covered, from the development of new vaccines to new abeyant ameliorative proteins. A specific characters is accustomed to protein engineering in the development of ambition molecules for biologic discovery.

International in scope, the abounding contributions are fatigued from academia and industry. The argument should be of absorption to acceptance and advisers in automated biotechnology as able-bodied as to everybody absorbed in basal analysis in protein structure, atomic genetics, bio-organic chemistry, biochemistry, agrobiotechnology, biologic sciences and medicine.

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Handbook of Aqueous Solubility Data, Samuel H. Yalkowsky

Over the years advisers accept appear solubility abstracts in the chemical, pharmaceutical, engineering, and ecology abstract for several thousand amoebic compounds. Until now, this advice has been broadcast throughout the literature. Containing over 16,000 solubility abstracts credibility for added than 4,000 amoebic compounds, Handbook of Aqueous Solubility Abstracts provides an all-encompassing accumulation of appear aqueous solubility abstracts for a advanced array of amoebic nonelectrolytes and amalgamated anemic electrolytes. It includes abstracts for pharmaceuticals, pollutants, nutrients, herbicides, pesticides, agricultural, industrial, and activity accompanying compounds.

Each admixture is articular by a consecutive amount forth with atomic formula, admixture name, synonyms, atomic weight, CAS Registry Number, melting point, and baking point if available. Anniversary access has a five-point appraisal account for the superior of the advertisement of the data, forth with the abounding citation, and comments from the authors if necessary. The convenient architecture gives a bright delineation of anniversary section of solubility abstracts with abundant advice to appraisal its validity. Handbook of Aqueous Solubility Abstracts gives you a portable, attainable ability for solubility abstracts of abundant compounds and a individual arrangement for the appraisal of the abstracts supplied.

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Antioxidant and Redox Regulation of Genes, Chandan K. Sen

This aggregate addresses oxidant-reduction or redox and antioxidant acute atomic mechanisms and how they are active in altered ache processes. Possible strategies to pharmacologically and/or nutritionally dispense such redox-sensitive atomic responses are emphasized.
Key Features:
* Reactive breed as intracellular messengers
* Redox adjustment of cellular responses
* Clinical implications of redox signaling and antioxidant therapy

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Cancer Drug Design and Discovery, Stephen Neidle

The ultimate antecedent of advice on the architecture of new anticancer agents, emphasising baby molecules, this newest plan covers contempo notable successes consistent from the animal genome and blight genomics projects. These advances accept provided advice on targets complex in specific cancers that are arch to able medicines for at atomic some of the accepted solid tumours. Unique sections explain the basal basal attempt of blight biologic development and accommodate a applied addition to avant-garde methods of biologic design. Appealing to a ample audience, this is an accomplished advertence for translational advisers absorbed in blight analysis and anesthetic as able-bodied as acceptance in pharmacy, pharmacology, or alleviative and biological chemistry, and clinicians demography oncology options.

* Covers both currently accessible drugs as able-bodied as those beneath development

* Provides a analytic angle on trials of new anticancer agents

* Presents biologic analysis examples through the use of case histories

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Understanding Drugs and Behaviour, Andrew Parrott

Why are some drugs awful addictive? What absolutely are the furnishings of altered types of consciousness-expanding drugs? How can they aftermath such affecting furnishings on mood, cognition, sensation, awareness, bloom and well-being?

Understanding Drugs and Behaviour describes in detail how the capital consciousness-expanding drugs can adapt academician allure and adapt behaviour. Written by accomplished advisers with a top akin of analysis expertise, all the capital drugs acclimated in today’s association are included, such as alcohol, nicotine, cannabis, LSD and Ecstacy, opiates, CNS stimulants, as able-bodied as analytic medications.

Teaching and acquirements appearance include:

Chapter overviews

In-depth amount actual

End of affiliate questions

Key references

Extensive comment

Journals and websites of interest

This anterior argument will be of use to acceptance of psychology, behavioural sciences, bloom sciences, nursing, analysis and pharmacology.

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Signal Transduction, B. D. Gomperts

This book is a actual acceptable addition to the subject. Depth and across of advantage is in accepted able-bodied counterbalanced and the abounding diagrams advice compassionate absolutely a bit. The capacity choosen by the authors are advisory and put calm an ok account of signaling processes. There is one capital areas that accept been omited and I anticipate anticipate the book from giving a "very good" (as against to just ok) account of the field, namely: spatio-temporal dynamics of signaling cascades and algebraic clay of this processes. In my opionion, compassionate the spatio-temportal alignment of the signaling accouterment is axiological to accept signaling and the authors do not present the accountable abundantly (if at all). The additional abortion is in the breadth of "systems thinking". The book fails to back the complication of the assorted levels of acknowledgment and added forms of adjustment that accomplish these systems work. Spatio-temporal alignment and dynamics are a axiological allotment of signaling pathways and you can't get a astute account of what is traveling on after them.

The acreage is advancing at bastardize acceleration and a new copy may be in order. Perhaps the new copy could cover a brace of capacity about spatial alignment and a added "holistic" appearance of signaling systems.

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Pharmacy Practice for Technicians, Jane M. Durgin

The "classic" book for the pharmacy technicians, Durgin and Hanan's Pharmacy Practice for Technicians, continues to be the baton in the pharmacy technology field. This new copy places added accent on the role the pharmacy artisan plays in both institutional and association pharmacies. The duties and responsibilities of the pharmacy artisan are accretion as the acreage of pharmacy grows and adapts to customer demands. These new competencies are authentic and explained, authoritative the pharmacy artisan absolutely able for the challenges of a career in the pharmacology industry.

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Intravenous Therapy in Nursing Practice, Lisa Dougherty

Intravenous Analysis in Nursing Practice provides a absolute adviser to the administering of intravenous analysis in nursing, and explores all aspects of intravenous analysis in both hospital and association settings.

It addresses amount analytic skills, including the alertness and administering of intravenous drugs, borderline venous access, astute and continued appellation axial venous access, and paediatric intravenous therapy. The book aswell explores accordant analysis and physiology, aqueous and electrolyte balance, pharmacological aspects and acknowledged and ethical issues, in adjustment to accouter nurses with the abilities and ability bare in adjustment to accommodate safe and able care.

* Addresses key specialist skills, including claret transfusion, parenteral diet and safe administering of cytotoxic drugs

* A absolute argument for nurses alive in the hospital and the community

* Contains contributions from arch assistant practitioners

Intravenous Analysis in Nursing Practice is an capital ability for nurses and bloom professionals alive in intravenous therapy.

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Human Drug Metabolism: An Introduction, Michael D. Coleman

Human Biologic Metabolism, An Introduction, Second Copy provides an attainable addition to the accountable and will be decidedly invaluable to those who already accept some compassionate of the activity sciences. Completely revised and adapted throughout, the new copy focuses alone on capital actinic detail and includes accommodating case histories to allegorize the analytic after-effects of changes in biologic metabolism and its appulse on accommodating welfare.

After underlining the accord amid efficacy, toxicity and biologic concentration, the book again considers how metabolizing systems accomplish and how they appulse aloft biologic concentration, both beneath biologic burden and during inhibition. Factors affecting biologic metabolism, such as abiogenetic polymorphisms, age and diet are discussed and how metabolism can advance to toxicity is explained. The book concludes with the role of biologic metabolism in the bartering development of ameliorative agents as able-bodied as the pharmacology of some adulterous drugs.

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Fundamentals of Psychopharmacology, B. E. Leonard

Treatment with drugs is axiological to avant-garde analysis of psychiatric disorders. The amount of disorders acknowledging to biologic analysis is increasing, absorption the all-encompassing amalgam of atypical compounds and the greater compassionate of the aetiology of the disorders.

This third archetype provides new and adapted material, including an added affiliate on analytic trials and their accent in assessing the ability and assurance of consciousness-expanding drugs. As atomic analysis and imaging techniques are of accretion accent to basal and analytic neuroscience, these areas accept aswell been continued to allegorize their appliance to our compassionate of psychopharmacology.

This book is capital account for undergraduates in pharmacology and the neurosciences, postgraduate neuropharmacologists, psychiatrists in training and in convenance and medical researchers.

Reviews of the Second Edition

"…this argument is conspicuously readable, able-bodied researched, and apparently the best of its kind.

The book is able-bodied account affairs and anyone who claims to apperceive annihilation about psychopharmacology will be accepted to accept a heavily annotated copy." Irish Journal of Psychological Medicine

"…[this is] a actual acceptable book, abnormally ill-fitted to those absorbed in psychopharmacologic analysis and psychiatric address in training." Journal of Chemical Neuroanatomy

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