This can be a second version to the original published by Springer in 2006. The comprehensive volume takes a textbook approach systematically developing the field by starting from linear models and then transferring up to generalized linear and non-linear mixed results models. Since the first version was published the sphere has grown considerably by way of maturity and technicality. The second edition of the e-book subsequently significantly expands with the addition of three new chapters referring to Bayesian models, Generalized linear and nonlinear mixed effects models, and Principles of simulation. In addition, many of the different chapters have been expanded and updated.
I have been teaching modeling and simulation for a number of years. By itself, Chapter 1: "The Art of Modeling", is simply a superb overview of the subject; and not solely applies to pharmacokinetic-pharmacodynamic modeling, but to modeling in general. It covers the same old suspects: what is a model, sorts of models, properties of a useful mannequin, model improvement course of, goodness-of-match standards and metrics, and model validation. Moreover, provides an excellent introduction to delicate but important matters, such as: model discrimination criteria (AIC, F-test, etc.), identifiability of compartmental models, significance of effective communication and ethics in modeling. I've not gone via the small print in all the opposite chapters, however given my good impression based mostly in Chapter 1, I am certain that this textbook will grow to be a must learn to any critical modeler in the discipline of pharmacokinetic-pharmacodynamic.
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