The molecular biological revolution and the mapping of the human genome continue to offer new challenges and alternatives for drug analysis and design. Future medicinal chemists and drug designers must have a agency background in a lot of related scientific disciplines with a purpose to understand the conversion of latest insight into lead buildings and subsequently into drug candidates. Classroom tested and pupil authorized, Textbook of Drug Design and Discovery, Fourth Version describes the style in which medicinal chemists utilize the assorted fields upon which they draw and the particular methods they employ to advance promising molecules into clinical use for the therapy of disease.
This text integrates a lot of associated scientific disciplines, together with superior synthetic chemistry, computational chemistry, biochemistry, structural biology, and molecular pharmacology, to supply present and comprehensive information on all elements of drug design and discovery.
Extensively revised, new matters in the fourth version embody:
Biostructure-based and ligand-based drug design
Chemical biology
Natural products
Imaging
Neurotransmitter transporters
Opioid and cannabinoid receptors
Hypnotics
Uncared for illnesses
Immunomodulating agents
Antibiotics
The first part of the e-book covers common facets, strategies, and rules for drug design and discovery, and the second half covers specific targets and diseases. The text incorporates greater than 300 colour figures and 24 tables for fast assimilation. Each chapter contains references for further study. Most chapters also provide the background and historical past needed to supply a context for college kids, in addition to conclusions that summarize the points most relevant to rising areas of analysis in drug design.
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