I'm a couple of 150 pages in and I find the material fascinating. It is truly amazing all the effort that has been utilized to the development of those CNS drugs. However, one thing that has begun to bother the heck out of me is the depiction of chemical constructions for various drugs described within. The choice of format is inconsistent. For example, the depiction of alkyl chains switches from condensed format (i.e. lines, like how it will be produced in ChemDraw) to expanded (i.e. writing out CH2-CH2-CH3) for no reason at all (and generally within the same molecule). Another example, one drug structure had an aryl halide bond however the construction did not specify the position on the ring. I discovered myself looking the generic drug title in Wikipedia or Google just to find a better structure image. Possibly it's because I used to be trained as an organic chemist, however I discover this lack of consideration to element simply lazy.
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http://rapidgator.net/file/73334462/0849387876.pdf.html
http://rapidgator.net/file/73334462/0849387876.pdf.html
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